An Advanced Echocardiographic Evaluation of Nebivolol

Stopped early · Phase 4

Conditions studied: Hypertension

In brief

The purpose of this study is to determine if Nebivolol has any effect on heart function determined by changes in echocardiographic data or exercise tolerance.

Key facts

Study ID

NCT01206439

Run by

Jack Rubinstein

People needed

2

Starts

2010-09-01

Expected to finish

2012-08-01

Last updated by the study team

2018-02-15

Who can join

Age: 20 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of hypertension
• Written informed consent before initiation of any study related procedure
• Baseline Blood pressure > 140 systolic or >90 diastolic if on no antihypertensive therapy.
• Currently taking one antihypertensive or one antihypertensive and one diuretic for the treatment of hypertension.

You may not qualify if…

• Physical limitations resulting in a limited ability to walk on treadmill for stress echo
• Intolerance to beta blockers
• On more than one medication for the treatment of hypertension unless the second medication is a diuretic.
• Currently pregnant or breast feeding.
• LFT > 3 X ULN
• HgA1C > 7
• Participation in other clinical research studies involving the evaluation of other investigational drugs or devices within past 30 days of enrollment
• Unwilling to follow protocol or return for study related procedures.
• Any of the following conditions:
• Coronary artery disease Heart failure Valvular heart disease Ischemic heart disease Atrial fibrillation Pacemaker ICD Hyperlipidemia Diabetes Mellitus Stroke/TIA Anemia COPD Asthma Renal failure requiring dialysis Liver failure Cirrhosis Thyroid dysfunction
• Any other medical condition that in the PI's opinion could affect myocardial function.
• Current ETOH or illicit drug abuse -

Where it is running

• University of Cincinnati — Cincinnati, Ohio, United States

Full record on ClinicalTrials.gov

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