Immune Mediated Disorders After Allogeneic Hematopoietic Cell Transplantation

Completed

Conditions studied: Graft vs Host Disease, Cutaneous Sclerosis, Bronchiolitis Obliterans

In brief

The purpose of this research study is to better understand the onset and course of graft versus host disease (GVHD)and other immune-mediated disorders after stem cell transplant.

Key facts

Study ID

NCT01206309

Run by

Fred Hutchinson Cancer Center

People needed

911

Starts

2011-03-01

Expected to finish

2016-10-01

Last updated by the study team

2016-10-07

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Planned or completed first allogeneic stem cell transplant (any conditioning regimen, graft source, donor type and GVHD prophylaxis regimen)
• Signed, informed consent and, if applicable, child assent

You may not qualify if…

• Inability to comply with study procedures
• Anticipated survival less than 6 months due to co-morbid disease
• Autoimmune disorder or inherited immunodeficiency before HCT
• Diagnosis of late acute or chronic GVHD prior to study enrollment
• Hematologic relapse or chemotherapy refractory disease at restaging within 1 month of HCT or at the time of enrollment (e.g., > 5% blasts for leukemia; poorly responsive lymphoma)

Where it is running

• Mayo Clinic — Scottsdale, Arizona, United States
• Stanford University — Stanford, California, United States
• H. Lee Moffitt Cancer Center — Tampa, Florida, United States
• Dana Farber Cancer Institute — Boston, Massachusetts, United States
• University of Minnesota — Minneapolis, Minnesota, United States
• Washington University St. Louis — St Louis, Missouri, United States
• Roswell Park Cancer Institute — Buffalo, New York, United States
• Weill Cornell Medical College — New York, New York, United States
• University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States
• Cleveland Clinic Foundation — Cleveland, Ohio, United States
• The Ohio State University — Columbus, Ohio, United States
• Vanderbilt University — Nashville, Tennessee, United States
• Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance — Seattle, Washington, United States
• Medical College of Wisconsin — Milwaukee, Wisconsin, United States

Full record on ClinicalTrials.gov

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