Efficacy and Safety of Liraglutide in Subjects With Type 1 Diabetes Undergoing Islet Cell Transplantation

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Diabetes, Diabetes Mellitus, Type 1

In brief

This trial is conducted in Europe and North America. The aim of this trial is to investigate if liraglutide treatment can increase the proportion of insulin-independent subjects one year after islet cell transplantation who required only one (single-donor) islet cell transplant.

Key facts

Study ID

NCT01206101

Run by

Novo Nordisk A/S

People needed

3

Starts

2012-03-21

Expected to finish

2013-06-03

Last updated by the study team

2017-03-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Type 1 diabetes mellitus for at least 5 years
• Candidate for islet cell transplantation based upon local accepted practice and guidelines
• Reduced awareness of hypoglycaemia

You may not qualify if…

• Treatment with any anti-diabetic medication other than insulin including insulin pump within 4 weeks of trial start
• Any previous organ transplantation
• A history of acute idiopathic or chronic pancreatitis
• Family or personal history of multiple endocrine neoplasia type 2 (MEN2) or familial medullary thyroid carcinoma (FMTC)

Where it is running

• Novo Nordisk Investigational Site — Duarte, California, United States
• Novo Nordisk Investigational Site — Chicago, Illinois, United States
• Novo Nordisk Investigational Site — Boston, Massachusetts, United States
• Novo Nordisk Investigational Site — Madison, Wisconsin, United States
• Novo Nordisk Investigational Site — Edmonton, Alberta, Canada
• Novo Nordisk Investigational Site — Vancouver, British Columbia, Canada
• Novo Nordisk Investigational Site — Besançon, France
• Novo Nordisk Investigational Site — Grenoble, France
• Novo Nordisk Investigational Site — Lille, France
• Novo Nordisk Investigational Site — Montpellier, France
• Novo Nordisk Investigational Site — Strasbourg, France
• Novo Nordisk Investigational Site — Dresden, Germany
• Novo Nordisk Investigational Site — Geneva, Switzerland
• Novo Nordisk Investigational Site — Zurich, Switzerland
• Novo Nordisk Investigational Site — Headington, United Kingdom
• Novo Nordisk Investigational Site — London, United Kingdom

Full record on ClinicalTrials.gov

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