Teaching Math Skills to Individuals With Fragile X Syndrome

Completed · Not applicable

Conditions studied: Developmental Disabilities, Fragile X Syndrome

In brief

Children with FXS are predisposed to manifesting a particular profile of intellectual strengths and weaknesses, including specific deficits in math, visual-spatial skills, executive functioning, and social skills. Until now, intensive behavioral interventions have not been targeted to syndrome-specific weaknesses. In the present study we will develop and evaluate behavioral strategies to aid skill acquisition in children with FXS.

Key facts

Study ID

NCT01204151

Run by

Stanford University

People needed

60

Starts

2008-09-01

Expected to finish

2013-07-01

Last updated by the study team

2019-05-09

Who can join

Age: 10 and older, up to 23. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• (a) 10 to 23 years of age (this age range was chosen to maximize the probability that subjects will cooperate with the imaging procedures as well as benefit from the interventions),
• (b) in good physical health,
• (c) able to participate in the imaging component of the project,
• (d) IQ between 50 and 80. We have found that individuals with IQ's less than 50 points are generally unable to comply with the scanning procedures.
• (e) diagnosis of FXS (for FXS group) and non-specific developmental disorder (for control group).

You may not qualify if…

• Exclusion criteria include
• contraindications for MRI (e.g., pacemaker, braces),
• the presence of neurological or sensory problems not associated with the conditions of interest (e.g., head trauma, blindness), or inability to discontinue psychotropic medication for 4 weeks prior to the scan.
• Additional exclusion criteria for the control group include the presence of any known identifiable syndrome (e.g., fragile X syndrome, Down syndrome, Prader-Willi syndrome, Turner syndrome, PKU, fetal alcohol syndrome, Williams syndrome).

Where it is running

• Stanford University School of Medicine — Stanford, California, United States

Full record on ClinicalTrials.gov

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