Early Propranolol After Traumatic Brain Injury: Phase II
Stopped early · Phase 2
Conditions studied: Traumatic Brain Injury
In brief
The primary objective of this study is to determine in patients with traumatic brain injury (TBI) the safe dosing of propranolol. Safety will be measured by episodes of bradycardia (heart rate \< 60 beats per minute), hypotension (defined as systolic blood pressure \< 90) or decreased cerebral perfusion pressure (defined as CPP less than 60mmHg) that are refractive to Brain Trauma Foundation guidelines for treatment. A no-treatment arm will establish the number of episodes of bradycardia, hypotension and reduced cerebral pressure refractory to treatment that occur without propranolol.
Key facts
- Study ID
- NCT01202110
- Run by
- Cedars-Sinai Medical Center
- People needed
- 10
- Starts
- 2010-06-01
- Expected to finish
- 2015-02-01
- Last updated by the study team
- 2016-05-13
Who can join
Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- patients who present within 6 hours of traumatic brain injury who have 1) a Glasgow Coma Scale (GCS) score of ≤8 or a GCS of 9-12 with computerized tomography brain scans demonstrating brain injury.
You may not qualify if…
- pregnancy,
- patients already treated with beta-blockers,
- patients treated for antiarrhythmic, immunosuppressive or antiinfective treatment,
- myocardial infarction during the last 3 months,
- unstable or severe heart disease,
- severe chronic obstructive pulmonary disease,
- serious liver disease,
- cardiac ischemia that prevents the initiation of vasopressors,
- signs of cardiac arrhythmia or heart block on EKG,
- ischemic limb disease that prevents the initiation of vasopressors, vasopressors at maximum dose defined as norepinephrine at 40µg/min or neosynephrine at 300µg/min.
Where it is running
- Cedars-Sinai Medical Center — Los Angeles, California, United States
Full record on ClinicalTrials.gov
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