Effects of Salsalate on Prandial-Induced Vascular Inflammation After Spinal Cord Injury (SCI)

Completed · Not applicable · Has a placebo group

Conditions studied: Spinal Cord Injury

In brief

The overall study objectives are to examine whether: 1. Persons with spinal cord injury (SCI) having elevated body mass are at greater cardiovascular disease (CVD) risk for fasting and postprandial lipidemia, glycemia, and vascular inflammation than persons with SCI having 'normal' body mass, and 2. An inexpensive, low-risk, widely-available pharmacotherapy safely reduces CVD risks associated with fasting and postprandial lipidemia, glycemia, and vascular inflammation.

Key facts

Study ID

NCT01201759

Run by

University of Miami

People needed

18

Starts

2009-07-01

Expected to finish

2012-05-01

Last updated by the study team

2015-06-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• SCI resulting in tetraplegia at C3-C7
• injury for more than one year

You may not qualify if…

• 1. any recent dietary or other lifestyle changes;
• 2. diabetes or inflammatory medical conditions;
• 3. a pressure ulcer;
• 4. lung or bladder infection;
• 5. undiagnosed illness or fever;
• 6. recent surgery;
• 7. stomach ulcer or a history of stomach upset when taking aspirin or medicines like aspirin, or ,
• 8. currently taking medicines used for pain or inflammation (aspirin and non-steroidal anti-inflammatory drugs, corticosteroids), blood vessel diseases (statins or fibric acid derivatives), blood clotting disorders (Coumadin, Plavix), infections (antibiotics), diabetes (Metformin), and burning 'central' pain (voltage regulators).

Where it is running

• The Miami Project to Cure Paralysis — Miami, Florida, United States

Full record on ClinicalTrials.gov

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