Megestrol Acetate in Treating Weight Loss or Anorexia in Young Patients With Malignancies Who Are Undergoing Radiation Therapy and/or Chemotherapy

Stopped early · Phase 2

Conditions studied: Anorexia, Weight Changes

In brief

RATIONALE: Megestrol acetate may help improve appetite and lessen weight loss caused by cancer. PURPOSE: This clinical trial studies megestrol acetate in treating weight loss or anorexia in young patients with malignancies who are undergoing radiation therapy and/or chemotherapy.

Key facts

Study ID

NCT01200602

Run by

Mayo Clinic

People needed

1

Starts

2011-03-01

Expected to finish

2012-01-01

Last updated by the study team

2015-11-25

Who can join

Age: any, up to 21. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Any pediatric patient with an underlying diagnosis of a malignancy (excluding hematological malignancies like leukemias and lymphomas)
• ≥5% weight loss from diagnosis of primary malignancy (must be currently on chemotherapy and/or radiation therapy or scheduled to receive cancer therapy OR ≥5% weight loss following bone marrow transplant (autologous or allogeneic blood/bone marrow) and not actively receiving corticosteroid therapy
• Negative pregnancy test done =< 7 days prior to registration for women of childbearing potential only

You may not qualify if…

• Receiving tube feedings or parenteral nutrition
• Evidence of ascites
• Current (within the past 28 days) or planned treatment with adrenal steroids (short-term use of dexamethasone around days of intravenous chemotherapy is allowed for protection against emesis), androgens, progestational agents, or appetite stimulants (e.g., dronabinol)
• Known mechanical obstruction of the alimentary tract, malabsorption, or intractable vomiting (> 5 episodes/week)
• History of unresectable brain tumor or cancer metastatic to the brain
• History of thromboembolic disease
• Insulin-requiring diabetes
• Congestive heart failure and/or uncontrolled hypertension
• Anticoagulation
• Previous history of thrombosis (personal and immediate family)
• Concurrent corticosteroid therapy (except as an antiemetic)

Where it is running

• Mayo Clinic — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

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