Optimizing Ovulation Induction in the Poor Responder

Withdrawn before enrolling · Not applicable

Conditions studied: IVF Poor Responders

In brief

The purpose of this randomized controlled trial is to compare the efficacy and effect of luteal estradiol and combined oral contraceptive pills (COPC) on follicle recruitment and synchrony in a poor responder population. The randomized groups consist of: 1. patients receiving luteal estradiol prior to ovulation induction; and 2. patients receiving COCPs for 1 month prior to ovulation induction. Follicle characteristics and serum biomarkers will be followed and compared in each group. Coefficient of variation will be used to evaluate follicle size discrepancy. Chi square analysis will be used to compare categorical variables between treatment groups. Both estradiol and COPCs are used clinically in assisted reproduction, so this study affords no additional risks to the participants.

Key facts

Study ID

NCT01200537

Run by

Duke University

People needed

0

Starts

2010-10-01

Expected to finish

2012-10-01

Last updated by the study team

2012-11-21

Who can join

Age: 20 and older, up to 50. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Antral follicle count < 8
• Antimullerian hormone (AMH) <1.3
• Follicle stimulating hormone (FSH)>10
• History of follicular dysynchrony or poor response

You may not qualify if…

• Menopause
• FSH >40
• Age > 50
• Contraindication to estradiol or COCP (including pre-existing cardiovascular disease, familial thrombophilia (factor V Leiden), severe hypercholesterolemia, smoker over age 35) Ovulation induction during month of estradiol treatment

Where it is running

• Duke Fertility Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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