The Effects of Dexmedetomidine and Propofol on Cerebral Blood Flow and Brain Oxygenation During Deep Brain Stimulation

Completed · Not applicable

Conditions studied: Intracranial Neurosurgery

In brief

The investigators will evaluate the effects of dexmedetomidine and propofol on cerebral blood flow and brain oxygenation during Deep Brain Stimulation (DBS) surgery. Specifically, the investigators will test the hypothesis that dexmedetomidine is non-inferior to propofol for cerebral blood flow as measured by transcranial Doppler and brain oxygenation as measured by near-infrared spectroscopy.

Key facts

Study ID

NCT01200433

Run by

The Cleveland Clinic

People needed

44

Starts

2010-10-01

Expected to finish

2013-08-01

Last updated by the study team

2016-12-14

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ASA I-III.
• Scheduled for DBS.

You may not qualify if…

• History of dystonia.
• Severe heart failure with ejection fraction less than 30%.
• History of obstructive sleep apnea.
• History of renal failure with creatinine level > 2 mg/dl.
• Allergies to α-2 agonists and propofol.
• Current use of α-2 agonist medications such as clonidine.

Where it is running

• Cleveland Clinic Foundation — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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