POCD in Elderly Patients Following Desflurane or Sevoflurane General Anesthesia

Completed

Conditions studied: 1. Postoperative Cognitive Dysfunction

In brief

The use of desflurane in elderly subjects (\>65 years old) undergoing general anesthesia with endotracheal intubation will result in decreased POCD compared to sevoflurane if the patient's MAP is within 20% of the patient's baseline and the cerebral suppression state index stays within the moderately anesthetized range during general anesthesia.

Key facts

Study ID

NCT01199913

Run by

Loma Linda University

People needed

110

Starts

2010-08-01

Expected to finish

2014-08-01

Last updated by the study team

2014-09-09

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients (>65 years old)
• Scheduled for elective surgery requiring general anesthesia at LLUMC HSH
• Airway management expected to include endotracheal intubation
• Expected surgical duration 120 to 240 minutes

You may not qualify if…

• Pre-existing significant psychiatric disease or mental status changes
• Clinically significant cardiovascular, respiratory, hepatic, renal,neurological, psychiatric, or metabolic disease
• Patient's weighing >50% ideal body weight
• Men: Ideal Body Weight (in kilograms) = 50 + 2.3 kg per inch over 5 feet
• Women: Ideal Body Weight (in kilograms) = 45.5 + 2.3kg per inch over 5 feet
• Patients who have undergone a general anesthetic within the past 7 days
• Patient refusal

Where it is running

• Loma Linda University — Loma Linda, California, United States

Full record on ClinicalTrials.gov

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