A Study of RO5310074 in Patients With Psoriatic Arthritis

Completed · Phase 1 · Has a placebo group

Conditions studied: Arthritis, Psoriatic

In brief

This randomized, double-blind. placebo-controlled study will assess the safety, tolerability, pharmacokinetics and pharmacodynamics of multiple doses of RO5310074 in patients with psoriatic arthritis who have or have had an inadequate response to oral disease-modifying antirheumatic drugs (DMARDs) or non-steroidal anti-rheumatic drugs (NSAIDs). Patients will be randomized in cohorts to receive either 6 intravenous doses of RO5310074 or placebo. Anticipated time on study treatment is 12 weeks.

Key facts

Study ID

NCT01199809

Run by

Hoffmann-La Roche

People needed

19

Starts

2011-02-01

Expected to finish

2012-02-01

Last updated by the study team

2016-10-27

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients, 18 - 75 years of age
• Diagnosis of Psoriatic Arthritis (Moll and Wright or CASPAR criteria) of >/= 6 months duration
• Have >/= 3 swollen and >/= 3 tender joints
• Inadequate response to a current or previous oral DMARD or NSAID therapy
• Current oral DMARDs must be at stable dose for the appropriate duration (e.g. 14 days for sulfasalazine and 28 days for methotrexate or oral steroids)
• NSAIDs up to maximum recommended dose are permitted if at stable dose for at least 14 days prior to first dose of study drug, but not more than one NSAID simultaneously (except for low-dose aspirin for cardioprotection)
• Body mass index (BMI) 18 - 42 kg/m2 inclusive

You may not qualify if…

• Previous prolonged treatment with a biologic DMARD; use of biologic DMARD within 3 months or 5 times its elimination half-live (whichever is longer) prior to first dose of study drug
• Previous use of B-cell depleting biologic DMARDs
• Any previous treatment with alkylating agents such a cyclophosphamide or chlorambucil or with total lymphoid irradiation
• History of or current inflammatory joint disease other than psoriatic arthritis; Gout or pseudogout that is current or has been active within the past 6 months
• Positive for hepatitis B, hepatitis C or HIV infection
• Any acquired or congenital immune deficiency or history of disease known to cause significant alteration in immunologic function
• Acute clinically significant infection in the 6 weeks prior to administration of study drug, history or presence of chronic infection, or history of recurrent infection as an adult

Where it is running

• Study site — Anniston, Alabama, United States
• Study site — Los Angeles, California, United States
• Study site — Miami, Florida, United States
• Study site — Duncansville, Pennsylvania, United States
• Study site — Dallas, Texas, United States
• Study site — San Antonio, Texas, United States
• Study site — Melbourne, Victoria, Australia
• Study site — Nedlands, Western Australia, Australia
• Study site — Christchurch, New Zealand

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.