Impact of Physical Activity on Left Ventricular Mass and Lipid Metabolism

Stopped early

Conditions studied: Left Ventricular Hypertrophy

In brief

Prospective study on the structural and functional changes in the heart of adult women assessed by echocardiogram and in lipid metabolism that occur in response to physical training. Using echocardiogram we will characterize the early determinants of "athletic remodeling". We will also assess the effect of intense physical training on lipid metabolism, focus on HDL subspecies and function.

Key facts

Study ID

NCT01199211

Run by

University of California, San Francisco

People needed

187

Starts

2011-02-01

Expected to finish

2017-10-01

Last updated by the study team

2020-07-31

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy adult men or women, aged 18 years or older
• Voluntarily signed up for a sport event or to run a marathon or a half marathon for the first time
• Normal to mildly elevated blood pressure (systolic blood pressure < 140 mmHg and/or diastolic blood pressure < 90 mmHg)
• Hormone replacement therapy and birth control pills are allowed, provided they have been on a stable dose for more than 3 months and no change in dose is planned for the duration of the study
• Capable and willing to provide written, informed consent for the study

You may not qualify if…

• History of cardiovascular disease within the past year (cardiomyopathy, heart failure, ischemic heart disease, stroke, TIA, peripheral vascular disease)
• Change in body weight more than 10% over the past year
• History of significant medical conditions, including respiratory, gastrointestinal, neuromuscular, neurological or musculoskeletal problems interfering with exercise.
• Autoimmune or collagen vascular diseases, chronic anemia,
• Malignancies in the past 5 years, with the exception of treated skin or breast cancer that did not require treatment with chemotherapy.
• Diabetes
• Pregnancy or recent delivery: delivery date less than 3 months prior to enrollment
• Lipid lowering medications (statins, niacin, resins) are allowed, provided dose has not changed for 3 months prior to enrollment and is not anticipated to change during the study
• Fish Oil supplements are allowed, provided dose has been unchanged for 3 months prior to enrollment and no change in dose is planned for the duration of the study.

Where it is running

• CTSI - University of California San Francisco — San Francisco, California, United States

Full record on ClinicalTrials.gov

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