Study Evaluating The Safety Of AAB-003 (PF-05236812) In Subjects With Alzheimer's Disease

Completed · Phase 1 · Has a placebo group

Conditions studied: Alzheimer's Disease

In brief

This is a study to evaluate the safety of multiple doses of AAB-003 (PF-05236812) in patients with mild to moderate Alzheimer's Disease. Patients will receive either AAB-003 (PF-05236812) or placebo. Each patient's participation will last approximately 41 weeks.

Key facts

Study ID

NCT01193608

Run by

Pfizer

People needed

88

Starts

2010-09-01

Expected to finish

2013-10-01

Last updated by the study team

2017-02-23

Who can join

Age: 50 and older, up to 89. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of probable Alzheimer's Disease with MMSE score of 16-26, and brain MRI consistent with the diagnosis of Alzheimer's Disease
• Concurrent use of cholinesterase inhibitor or memantine allowed, if stable.
• Caregiver will participate and be able to attend clinic visits with patient

You may not qualify if…

• Significant neurological disease other than Alzheimer's Disease
• Major psychiatric disorder
• Contraindication to undergo brain MRI (e.g., pacemaker, CSF shunt, or foreign metal objects in the body)
• Women of childbearing potential

Where it is running

• Early Phase Investigational Center — Escondido, California, United States
• Synergy Clinical Research Center of Escondido — Escondido, California, United States
• MD Clinical — Hallandale, Florida, United States
• Franck's Pharmacy — Ocala, Florida, United States
• Munroe Regional Medical Center — Ocala, Florida, United States
• Renstar Medical Research — Ocala, Florida, United States
• Advanced Imaging of Ocala — Ocala, Florida, United States
• Atlanta Center for Medical Research — Atlanta, Georgia, United States
• Foers Medical Arts Pharmacy — Bethesda, Maryland, United States
• CBH Health, LLC — Rockville, Maryland, United States
• Borgess Medical Center — Kalamazoo, Michigan, United States
• Borgess Research Institute — Kalamazoo, Michigan, United States
• KNI/Southwest Michigan Imaging Center, LLC — Kalamazoo, Michigan, United States
• Brentwood Behavioral Healthcare — Flowood, Mississippi, United States
• Marty's Pharmacy — Flowood, Mississippi, United States
• Precise Research Centers — Flowood, Mississippi, United States
• Millennium Psychiatric Associates, LLC — Creve Coeur, Missouri, United States
• DePaul Health Center — St Louis, Missouri, United States
• Memory Enhancement Center of America, Inc. — Eatontown, New Jersey, United States
• Pharmacare USA — Edison, New Jersey, United States
• Central Jersey Radiology — Oakhurst, New Jersey, United States
• Belmont Center for Comprehensive Treatment — Philadelphia, Pennsylvania, United States
• Albert Einstein Medical Center — Philadelphia, Pennsylvania, United States
• Seoul National University Bundang Hospital, Department of Neurology — Seongnam-si, Gyeonggi-do, South Korea
• Inha University Hospital, Department of Neurology — Incheon, South Korea

Full record on ClinicalTrials.gov

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