A Study of PNT2258 in Patients With Advanced Solid Tumors

Completed · Phase 1

Conditions studied: Cancer, Lymphoma, Prostate Cancer, Melanoma

In brief

This study is sponsored by Sierra Oncology, Inc. formerly ProNAi Therapeutics, Inc. The purpose of this research study is to evaluate the safety of the investigational drug PNT2258 in patients with advance tumors and see how it acts in the body.

Key facts

Study ID

NCT01191775

Run by

Sierra Oncology LLC - a GSK company

People needed

22

Starts

2010-08-01

Expected to finish

2012-04-01

Last updated by the study team

2023-04-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically confirmed, malignant solid tumor (measurable or non-measurable disease) and cannot be a candidate for known regimens or protocol treatments of higher efficacy or priority.
• Recovered to Grade 1 from all acute toxicities of prior therapies, except for residual toxicities, such as alopecia, which do not pose an ongoing medical risk.
• ECOG performance status of 0, 1, or 2.
• At least 18 years of age.
• Patients must have normal organ and marrow function as defined by:
• Absolute neutrophil count 1,500/µL
• Platelets 100,000/µL
• Total bilirubin within normal institutional limits
• AST(SGOT)/ALT(SGPT) 2.5 x institutional upper limit of normal (ULN) or 5.0 x ULN in patients with liver metastases
• Serum creatinine 1.5 x ULN or measured creatinine clearance of 60 mL/min/1.73 m2.
• Negative serum pregnancy test at the time of enrollment for women of child-bearing potential. For men and women of child-producing potential, use of effective contraceptive methods is required during the study.
• Ability to understand the requirements of the study. Must provide written informed consent and authorization of use and disclosure of protected health information. Must agree to abide by the study restrictions and to return for the required assessments.

You may not qualify if…

• Received previous anticancer chemotherapy, immunotherapy, radiotherapy or any other investigational therapy in the 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to study entry.
• Receiving any other investigational agents.
• Known brain metastases with the exception of patients with a history of treated brain metastases who are stable for at least 3 months off glucocorticoids and seizure medications.
• Prolongation of QT/QTc interval > 450 milliseconds (ms).
• Known HIV, HBV, or HCV infection.
• History of allergic reactions attributed to compounds of similar chemical or biologic composition to PNT2258.
• History of allergic reaction to egg or chicken antigens.
• Pregnant or nursing women.
• Uncontrolled intercurrent illness including, but not limited to ongoing or serious active infection, symptomatic congestive heart failure, unstable angina pectoris, serious cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.

Where it is running

• South Texas Accelerated Research Therapeutics (START) — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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