Chronic Muscle Disuse in the Elderly

Completed · Not applicable

Conditions studied: Osteoarthritis

In brief

The purpose of this study is to define the effects of chronic disuse on skeletal muscle structure and function in elderly individuals at the cellular and molecular level by examining elderly characterized by chronic muscle disuse (patients with knee osteoarthritis) and healthy elderly no evidence of knee osteoarthritis and normal physical activity levels.

Key facts

Study ID

NCT01190046

Run by

University of Vermont

People needed

35

Starts

2010-10-01

Expected to finish

2016-06-01

Last updated by the study team

2016-11-16

Who can join

Age: 60 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 60-80 yrs of age
• physician-diagnosed, symptomatic knee osteoarthritis
• ambulatory and able to perform lower extremity resistance exercise

You may not qualify if…

• rheumatoid arthritis or other autoimmune disease
• chronic heart, lung, kidney or liver disease or hypertension
• diabetes
• history of stroke
• other neurological or musculoskeletal disease
• HEALTHY CONTROLS
• Criteria are identical to those for knee osteoarthritis patients above, but controls will have no clinical or radiographic evidence of osteoarthritis and will have normal activity physical activity levels.

Where it is running

• University of Vermont and State Agricultural College — Burlington, Vermont, United States

Full record on ClinicalTrials.gov

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