Characterization of Rectal Cancer Hypoxia Using pO2 Histography and Immunohistochemistry for Hypoxia-Related Proteins

Completed · Not applicable

Conditions studied: Rectal Cancer

In brief

The purpose of this study is to see if the cells in rectal cancer are oxygen-starved, or hypoxic. We know that as cancers grow bigger, parts of them are cut off from the oxygen supply and they become hypoxic, basically, lacking oxygen. Research has shown that cells that are oxygen-starved respond differently to treatment such as chemotherapy and radiation when compared to cells that are oxygen rich.

Key facts

Study ID

NCT01189877

Run by

Memorial Sloan Kettering Cancer Center

People needed

30

Starts

2010-08-01

Expected to finish

2012-10-01

Last updated by the study team

2012-10-11

Who can join

Age: 18 and older, up to 89. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Biopsy proven adenocarcinoma of the rectum. If a biopsy was taken at an outside hospital, the slides and diagnosis will be reviewed and confirmed by a pathologist at MSKCC.
• Mid to distal rectal tumors not requiring pre-op radiation or chemotherapy
• Age ≥ 18
• Age < 90
• Karnofsky performance status ≥ 60
• Ability to understand and the willingness to sign a written informed consent document.

You may not qualify if…

• Current pregnancy
• Uncontrolled intercurrent illness that would limit compliance with study requirements.

Where it is running

• Memorial Sloan Kettering Cancer Center — New York, New York, United States

Full record on ClinicalTrials.gov

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