Lipoic Acid for Secondary Progressive Multiple Sclerosis (MS)

Completed · Phase 2/Phase 3 · Has a placebo group

Conditions studied: Multiple Sclerosis, Chronic Progressive

In brief

The purpose of the study is to determine if lipoic acid can protect the brain and slow disability in secondary progressive multiple sclerosis.

Key facts

Study ID

NCT01188811

Run by

VA Office of Research and Development

People needed

54

Starts

2010-10-01

Expected to finish

2015-08-01

Last updated by the study team

2017-02-02

Who can join

Age: 40 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of SPMS
• Age 40-70 years
• Able to understand English and able to give informed consent

You may not qualify if…

• Unable to undergo MRI testing
• For ambulatory subjects only, a self-reported medical or neurological condition other than MS that is a cause of progressive or fluctuating problems that affect walking(e.g. worsening neuropathy, uncontrolled lower extremity arthritis, uncontrolled heart or lung disease)
• For ambulatory subjects only, fixed and/or stable conditions of less than 1 years duration that affect walking (e.g. joint replacement, lumbar stenosis, alcoholism, stroke, etc.)
• Pregnant or breast-feeding.
• Current major disease or disorder other than MS (such as cancer, kidney, heart or lung disease, post-traumatic stress disorder) that may interfere with study procedures
• Natalizumab, mitoxantrone, azathioprine taken in the last 12 months
• Other immunosuppressants or chemotherapies taken in the last 12 months
• Scheduled (every 3 months or more frequently) IV steroids used in the last 12 months
• IV or oral steroids taken in the past 60 days.
• Lipoic acid taken in the past 60 days.
• Subject has insulin-dependent diabetes or is not controlled on oral diabetes medications

Where it is running

• VA Portland Health Care System, Portland, OR — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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