The Effect of the Hyperinsulinemic Normoglycemic Clamp on Myocardial Function and Utilization of Glucose

Completed · Not applicable

Conditions studied: Hyperglycemia, Aortic Valve Replacement, Aortic Stenosis, Cardiac Surgery

In brief

The overall research plan is to test the hypothesis that intraoperative treatment of hyperinsulinemic normoglycemic clamp (HNC) in cardiac surgical patients improves myocardial function and short-term outcomes compared with standard glucose management.

Key facts

Study ID

NCT01187329

Run by

The Cleveland Clinic

People needed

100

Starts

2010-10-01

Expected to finish

2013-12-01

Last updated by the study team

2018-11-20

Who can join

Age: 40 and older, up to 84. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 40 - 84 years old, Aortic stenosis, Scheduled for Aortic valve replacement.

You may not qualify if…

• Poor quality echocardiographic images unsuitable for analysis
• Off -pump surgical procedure
• Anticipated deep hypothermic circulatory arrest
• Any contraindications to transesophageal echocardiogram (TEE) or other proposed intervention
• Unable to give written informed consent (non-English speaking, vulnerable patients, etc.)

Where it is running

• Cleveland Clinic Foundation — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.