ChloraPrep Versus Betadine for Elective Knee Replacement Surgery

Stopped early · Phase 4

Conditions studied: Arthroplasty, Knee Replacement, Replacement, Total Knee, Total Knee Replacement

In brief

This study will enroll patients who will be receiving primary total knee replacements. Subjects will be randomized into two groups: Betadine surgical scrub preparation and ChloraPrep preparation prior to total knee replacements. Study hypothesis: When used as a surgical scrub preparation prior to primary total knee arthroplasties, ChloraPrep (2% chlorhexadine gluconate and 70% isopropyl alcohol) is superior to Betadine (10% povidone iodine) in reducing incision site bacterial colony counts.

Key facts

Study ID

NCT01184196

Run by

Central DuPage Hospital

People needed

55

Starts

2009-11-01

Expected to finish

2012-12-01

Last updated by the study team

2013-04-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Scheduled to undergo primary total knee arthroplasty
• Age 18 or over

You may not qualify if…

• Inability to provide informed consent or to comply with study assessments due to cognitive impairment or geographic distance
• Age 17 or younger
• Allergies to chlorhexadine gluconate or povidone iodine
• Topical antimicrobial use within 14 days of surgery
• Any active dermatoses or open wounds over the operative site
• Any condition requiring antibiotics 14 days prior to arriving for surgery
• Patients with chronic immunosuppression (such as HIV/AIDS)
• Unable to adhere to follow up schedule and treatment

Where it is running

• Central DuPage Hospital — Winfield, Illinois, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.