Metabolically Normal and Metabolically Abnormal Obesity

Completed · Not applicable

Conditions studied: Obesity, Metabolic Syndrome

In brief

The purpose of this study is to learn more about why some obese persons are resistant to developing obesity-related metabolic diseases (such as diabetes and cardiovascular disease), while others are prone to developing these conditions. We will do this by studying obese persons before and after a 5% body weight gain. Subjects will be asked to increase their current diet for a period of 8-12 weeks in order to increase their current body weight by 5%. Each will then be asked to maintain this weight increase for 3 weeks. We will monitor subjects throughout this time period with weekly medical evaluations. At the completion of the study, we will provide each subject with a 6-month weight loss program.

Key facts

Study ID

NCT01184170

Run by

Washington University School of Medicine

People needed

71

Starts

2010-08-01

Expected to finish

2015-02-01

Last updated by the study team

2017-07-02

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Obese subjects (BMI 30.0 - 39.9 kg/m2)
• Sedentary subjects (exercise less than 1 hr/wk)

You may not qualify if…

• Pregnant or lactating women
• Michigan Alcohol Screening Test score ≥4
• Active or previous history of liver disease
• Active or previous history of diabetes
• history of alcohol abuse, or currently consuming ≥20 g alcohol/day
• Severe hypertriglyceridemia (>300 mg/dL)
• Smoke tobacco
• Take medication that might confound the study results

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.