Cognitive Control and Physical Exercise

Stopped early · Not applicable

Conditions studied: Cognitive Function, Day-to-Day Function

In brief

The purpose of this study is to test the hypothesis that aerobic exercise and a computer-based cognitive intervention leads to improved cognitive function accompanied by increases in gray matter density and changes in functional magnetic resonance imaging (fMRI) patterns of task-related activation.

Key facts

Study ID

NCT01183819

Run by

Columbia University

People needed

12

Starts

2010-02-01

Expected to finish

2015-06-01

Last updated by the study team

2015-08-05

Who can join

Age: 60 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 60-75
• English-speaking
• Strongly right-handed
• BMI > 18.5 and < 32
• Post-menopausal (women only): no estrogen replacement therapy
• Sedentary: VO2max < 36 ml/kg/min for men age 60-75; < 29 ml/kg/min for women age 60-75 (determined using Jones Formula Men = (60-(0.55*AGE)) Women = (48-(.37*AGE))

You may not qualify if…

• MRI contraindications (e.g., metallic implants, pacemaker, weight > 350 lbs, waist > 55")
• Hearing impaired/hearing aids, unable to read newspaper at arm's length with corrective lenses
• Objective cognitive impairment
• Ischemic changes, abnormal blood pressure responses, or any significant ectopy during aerobic capacity testing
• Cardiovascular disease
• Uncontrolled high blood pressure (systolic blood pressure ≥ 180 mmHg; or diastolic blood pressure ≥ 105 mmHg on two measures)
• Current or recent (evidence of disease x 5 years) non-skin neoplastic disease or melanoma
• Active hepatic disease (not a history of hepatitis) or primary renal disease requiring dialysis, primary untreated endocrine diseases, e.g., Cushing's disease or primary hypothalamic failure or insulin dependent diabetes (Type I or II).
• HIV infection
• Pregnant or lactating (participation allowed 3 months after ceasing lactation
• Other medical disorders judge to interfere with study
• Medications that target CNS (e.g., neuroleptics, anticonvulsants, antidepressants, benzodiazepines) within the last month
• Women: any selective estrogen receptor modulator or aromatase inhibitor Men: androgen ablation/deprivation hormonal therapies
• Any history of psychosis or electroconvulsive therapy
• Psychotic disorder (lifetime)
• Current or recent (within past 12 months) alcohol or substance abuse or dependence. Recent use (past month) of recreational drugs.
• Brain disorder such as stroke, tumor, infection, epilepsy, multiple sclerosis, degenerative diseases, head injury, mental retardation
• Imaged cortical stroke or large subcortical lacunae or infarct or space-occupying lesion (≥ 2 cubic cm). Other findings, e.g., periventricular caps or small white matter hyperintensities, do not result in exclusion
• Diagnosed learning disability, dyslexia

Where it is running

• Columbia University Medical Center — New York, New York, United States

Full record on ClinicalTrials.gov

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