Prospective Review of Procalcitonin After Cardiac Surgery

Completed

Conditions studied: Procalcitonin, Coronary Artery Bypass Grafting

In brief

This study is designed to demonstrate the value of Procalcitonin (PCT) in assisting the rapid diagnosis of post- operative infection that includes elevation of Procalcitonin above and beyond the changes seen with the acute and inflammatory response induced by cardio-pulmonary bypass. Procalcitonin is an innovative and highly specific biomarker for clinically relevant severe bacterial infections and sepsis. PCT supports early diagnosis and clinical decision making.This is a prospective single center study designed to assess the normal change in PCT levels following major surgery and the utilization of PCT regarding the diagnosis of infection and the response to treatment, following major cardiac surgery

Key facts

Study ID

NCT01182688

Run by

Tampa Bay Heart Foundation

People needed

105

Starts

2009-05-01

Last updated by the study team

2010-08-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Elective CABG + / - Aortic / Mitral valve patients Off pump and on pump cases

You may not qualify if…

• Exclusion Criteria:
• Check any box that applies:
• Patients with recent infection in last week and / or Antibiotics in last 1 week or pre op fever > 99.5f / 38C in 24hrs prior to surgery Patients on oral or IV corticosteroids within 1 week of being on them. Known immune dysfunction Active congestive heart failure / Recovering from cardiogenic shock\\ Intra aortic balloon pump pre - op No CABG patients with CRYO MAZE, or Ablation

Where it is running

• Morton Plant Hospital — Clearwater, Florida, United States

Full record on ClinicalTrials.gov

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