The Effect of Prior Muscle Activation on the Compound Muscle Action Potential (CMAP)

Completed · Not applicable

Conditions studied: Focus: Effect of Muscle Activation on CMAP in Normal Humans

In brief

The purpose of this investigator-initiated study is to determine the effect of prior muscle activation on the response obtained by nerve conduction studies (the compound muscle action potential \[CMAP\]) looking at the amplitude, area, and duration of the CMAP and evaluating the length of time the CMAP is larger than at baseline. On the opposite side, the corresponding CMAP will be tested periodically, but there will be no muscle activation on that side. Null Hypothesis: While controlling all possible technical and other known physiological variables, prior activation of a muscle has no effect on the amplitude and area of the compound muscle action potential (CMAP); and the CMAP does not change over time in the relaxed muscle (on the opposite side). The investigators suspect that there is an effect of prior activation of the muscle on the subsequent CMAP recorded from that muscle.

Key facts

Study ID

NCT01182558

Run by

Loma Linda University

People needed

6

Starts

2010-10-01

Expected to finish

2019-08-01

Last updated by the study team

2019-08-14

Who can join

Age: 18 and older, up to 49. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Normal, healthy volunteers
• Age 18-49

You may not qualify if…

• Localized or generalized neuromuscular disorder
• History of neuropathy
• History of diabetes
• History of prior injuries or surgeries of the back, neck, or limbs to be tested which in the opinion of the investigator might have the potential to influence the compound muscle action potential
• Medications other than eyedrops or non-steroidal anti-inflammatory agents (as needed) or contraceptive agents or non-steroidal topical agents
• Abnormalities by screening nerve conduction studies
• Anomalous innervation of the tested extensor digitorum brevis via screening nerve conduction studies
• Use of caffeine or nicotine within 8 hours of testing

Where it is running

• Neurology - Faculty Physicians and Surgeons of Loma Linda University School of Medicine — Loma Linda, California, United States

Full record on ClinicalTrials.gov

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