The Importance of Periostin in Periodontal Health and Disease
Completed
Conditions studied: Periodontal Disease, Non-diseased Patients
In brief
The goal of this study is to determine the clinical importance of Periostin in oral health and disease. The long-term goal will be to develop practical applications for the diagnosis, treatment, prevention and cure of human periodontal diseases.
Key facts
- Study ID
- NCT01180920
- Run by
- University of Michigan
- People needed
- 22
- Starts
- 2011-06-01
- Expected to finish
- 2013-02-01
- Last updated by the study team
- 2014-12-02
Who can join
Age: 21 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Inclusion criteria for diseased subjects:
- Diagnosis of generalized chronic or aggressive periodontitis
- At least four periodontal sites with probing depth (PD) ≥6 mm, evidence of clinical attachment loss (CAL), and bleeding on probing (BOP). Inclusion criteria for healthy individuals will include PD <4 mm, no evidence of attachment loss, and <10% of sites with BOP
- Need an open flap procedure
- Inclusion criteria for non-diseased subjects:
- Subjects requiring a gingivectomy or crown lengthening procedure
You may not qualify if…
- History of alcoholism or drug abuse
- Medical conditions that may affect the outcome such as autoimmune diseases, diabetes, immunocompromised subjects, neurologic or psychiatric disorders, systemic infections, etc.
- Chronic medications known to affect the periodontal status (calcium antagonists, anticonvulsives, immunosuppressives, anti-inflammatory medications, Depo-Provera contraceptive injection users, new oral contraceptives users within 3 months of baseline or subjects that are planning on, starting oral contraceptives during the study.
- Antibiotic therapy within 3 months of the baseline visit, and/or antibiotic therapy needed for infective endocarditis prophylaxis.
- Current use or quit smoking less than one year ago with a pack-year history of more than or equal to 10.
- Untreated cavities
Where it is running
- Michigan Center for Oral Health Research — Ann Arbor, Michigan, United States
Full record on ClinicalTrials.gov
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