Comparison Of 2 Doses Of Temsirolimus (Torisel) In Patients With Mantle Cell Lymphoma

Completed · Phase 4

Conditions studied: Non-Hodgkin's Lymphoma

In brief

This study will compare the effectiveness and safety of two different doses of temsirolimus (Torisel).

Key facts

Study ID

NCT01180049

Run by

Pfizer

People needed

101

Starts

2011-03-01

Expected to finish

2018-06-01

Last updated by the study team

2019-05-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have confirmed mantle cell lymphoma diagnosis.
• Have measurable disease.
• Have received at least 2 prior treatment, which may include stem cell transplant.
• Have adequate organ and bone marrow function.
• There are other criteria--please discuss with your doctor.

You may not qualify if…

• Had any prior treatment with temsirolimus or mTOR inhibitor.
• Had allogeneic stem cell transplant within last 6 months and on immunosuppressive therapy.
• Has active or untreated brain or central nervous system metastases.
• There are other criteria--please discuss with your doctor.

Where it is running

• Mercy Research Institute — Miami, Florida, United States
• Veterans Affairs New Jersey Healthcare System-Hematology/Oncology Section (111) — East Orange, New Jersey, United States
• Mercy Clinic Oklahoma Communities dba Mercy Clinic Oncology/Hematology-McAuley — Oklahoma City, Oklahoma, United States
• Mercy Hospital Oklahoma City-Oncology Infusion — Oklahoma City, Oklahoma, United States
• Amy Shen, RPh — Seattle, Washington, United States
• VA Puget Sound Health Care System — Seattle, Washington, United States
• St George Hospital — Kogarah, New South Wales, Australia
• Royal Adelaide Hospital — Adelaide, South Australia, Australia
• Royal Hobart Hospital — Hobart, Tasmania, Australia
• Box Hill Hospital — Box Hill, Victoria, Australia
• The Alfred Hospital — Melbourne, Victoria, Australia
• Fakultni nemocnice Kralovske Vinohrady — Prague, Czech Republic, Czechia
• Fakultni nemocnice Kralovske Vinohrady — Prague, Czechia
• Vseobecna fakultni nemocnice v Praze — Prague, Czechia
• CHU de Nancy — Vandœuvre-lès-Nancy, France
• Klinik fuer Onkologie und Haematologie, Medizinische Klinik IV — Aachen, Germany
• Klinikum Johannes-Gutenberg -Universitaet, III. Medizinische Klinik und Poliklinik — Mainz, Germany
• Presidio Ferrarotto - A.O.U. - PoliclinicoVittorio Emanuele — Catania, Italy
• Dipartimento di Medicina Diagnostica, Clinica e di Sanità Pubblica — Modena, Italy
• Struttura Complessa di Ematologia, Dipartimento di Oncologia ed Ematologia- — Torino, Italy
• Malopolskie Centrum Medyczne S.C. — Krakow, Poland
• Institutul Clinic Fundeni Bucuresti, Sectia II Hematologie — Bucharest, Romania
• Spitalul Clinic Coltea, Clinica de Hematologie — Bucharest, Romania
• Spitalul Universitar de Urgenta Bucuresti, Clinica de Hematologie — Bucharest, Romania
• Republican Clinical Oncology Dispensary of the Ministry of Healthcare of Tatarstan Republic — Kazan', Russia

Full record on ClinicalTrials.gov

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