Effects of a Food Preservative on Glucose Homeostasis

Completed · Not applicable

Conditions studied: Overweight

In brief

The investigators propose to examine the effects of the common food preservative sodium benzoate on blood glucose and related hormones and metabolites. If an effect is demonstrated, patients with increased diabetes risk could be counseled to avoid this preservative.

Key facts

Study ID

NCT01179945

Run by

Boston Children's Hospital

People needed

13

Starts

2010-08-01

Expected to finish

2011-12-01

Last updated by the study team

2012-10-01

Who can join

Age: 18 and older, up to 35. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Men and women age 18-35
• BMI 25-30

You may not qualify if…

• Diabetes Mellitus (fasting Blood Glucose ≥ 126mg/dl)
• Exercise more than 60 minutes more that 4 times a week
• Major medical illness
• Medications or supplements that can influence glucose metabolism
• Large fluctuations in weight (>5% over the past 6 months)
• Currently following a weight loss program
• Consumption of more than 24 ounces of soda per day (defined as sugar- or artificially sweetened beverages, e.g. colas or fruit punches, excluding hot tea and coffee)
• Allergy or intolerance to sodium benzoate
• Nicotine use
• Illicit substance use
• Women with irregular menstrual cycles, or who are pregnant or breastfeeding

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States
• Children's Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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