Pilot Study of Sodium Nitrite in Resuscitated Cardiac Arrest Patients

Completed · Phase 1

Conditions studied: Cardiac Arrest

In brief

Despite advances in cardiac arrest resuscitation survival from cardiac arrest is less than 20-30% and new therapies are urgently needed. Sodium nitrite infused during resuscitation from cardiac arrest has recently been shown to improve survival in a mouse model of cardiac arrest and our group is eager to test this hypothesis in a clinical trial. Our overall hypothesis is that an infusion of 2 μmole/kg sodium nitrite during resuscitation will increase the proportion of patients who will survive cardiac arrest. In preparation for a clinical trial, preliminary safety and efficacy data (phase 1) is needed which is the primary goal of this study.

Key facts

Study ID

NCT01178359

Run by

University of Washington

People needed

11

Starts

2010-01-01

Expected to finish

2016-04-01

Last updated by the study team

2017-05-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Successfully resuscitated from cardiac arrest by paramedics in the field Age 18 or older Comatose IV access

You may not qualify if…

• traumatic cause of cardiac arrest known DNAR Patient requiring vasopressors at time of randomization SBP <105 PaO2 of less than 90% on FiO2 of 1.0

Where it is running

• Harborview Medical Center — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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