Carotid Plaque Characteristics by MRI in AIM-HIGH (Carotid MRI Substudy)

Completed

Conditions studied: Coronary Artery Disease, Carotid Artery Diseases, Atherosclerosis

In brief

Heart attacks and strokes caused by the unstable atherosclerotic plaques remain the leading cause of death in the United States. Unstable plaques often have more fat than stable plaques. This study will investigate if a treatment with LDL-lowering plus HDL-raising compared with LDL-lowering alone would more effectively reduce the plaque fat content assessed by magnetic resonance imaging (MRI), therefore, further reducing heart attacks and strokes.

Key facts

Study ID

NCT01178320

Run by

University of Washington

People needed

230

Starts

2008-03-01

Expected to finish

2015-02-01

Last updated by the study team

2018-02-09

Who can join

Age: 45 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Eligible for main AIM-HIGH study (NCT00120289)
• Medically able to undergo MRI procedure
• Willing to provide informed consent for participation in this substudy

You may not qualify if…

• Uses pacemaker or has metallic implants
• History of bilateral carotid endarterectomy
• Glomerular filtration rate less than 60 mL/min/1.73 m\^2

Where it is running

• Cardiovascular Consultants — Phoenix, Arizona, United States
• Long Beach VA Medical Center — Long Beach, California, United States
• University of Southern California — Los Angeles, California, United States
• University of Maryland — Baltimore, Maryland, United States
• Johns Hopkins University — Baltimore, Maryland, United States
• Mayo Clinic — Rochester, Minnesota, United States
• Duke University — Durham, North Carolina, United States
• Wake Forest University — Winston-Salem, North Carolina, United States
• Philadelphia VA Medical Center — Philadelphia, Pennsylvania, United States
• Baylor College of Medicine — Houston, Texas, United States
• Kelsey Research Foundation — Houston, Texas, United States
• Methodist Hospital — Houston, Texas, United States
• Harborview Medical Center — Seattle, Washington, United States
• University of Washington — Seattle, Washington, United States
• Puget Sound VA Medical Center, Seattle Campus — Seattle, Washington, United States
• Heart Health Institute — Calgary, Alberta, Canada
• University of Calgary — Calgary, Alberta, Canada
• Vancouver General Hospital — Vancouver, British Columbia, Canada
• University of Western Ontario — London, Ontario, Canada

Full record on ClinicalTrials.gov

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