Exercise Endothelial Progenitor Cells (EPCs) and Type 2 Diabetes

Running, not enrolling · Not applicable

Conditions studied: Type 2 Diabetes Mellitus

In brief

The discovery of the role of endothelial progenitor cells (EPCs) and their involvement in the cardiovascular complications of type 2 diabetes (T2DM) would quickly have a significant impact on the millions of Americans who have T2DM. This project is designed to 1) determine the mechanisms underlying EPC dysfunction in older, sedentary adults with T2DM compared those with normal glucose metabolism and impaired glucose metabolism, and 2) determine if aerobic exercise training is an efficacious therapy for EPC dysfunction in T2DM, and whether improvement in EPC number and function translates to improved endothelial function, increased capillarization, and improved glucose metabolism in T2DM.

Key facts

Study ID

NCT01176578

Run by

Baltimore VA Medical Center

People needed

70

Starts

2011-07-01

Expected to finish

2026-12-31

Last updated by the study team

2025-09-19

Who can join

Age: 50 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 50-80
• Non-smoker
• If woman, postmenopausal >1 year

You may not qualify if…

• History of heart disease or stroke
• Cancer
• Poorly controlled hypertension or dyslipidemia
• Kidney or Liver diseases

Where it is running

• Baltimore VA Medical Center — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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