Open-Label Study of Asfotase Alfa in Infants and Children ≤ 5 Years of Age With Hypophosphatasia (HPP)

Completed · Phase 2/Phase 3

Conditions studied: Hypophosphatasia

In brief

This clinical trial was conducted to study hypophosphatasia (HPP), a bone disorder caused by gene mutations or changes. These gene mutations cause low levels of an enzyme needed to harden bone. The purpose of this study was to test the safety and efficacy of a study drug called asfotase alfa (human recombinant tissue non-specific alkaline phosphate fusion protein) to see what effects it has on patients 5 years of age or less with HPP.

Key facts

Study ID

NCT01176266

Run by

Alexion Pharmaceuticals, Inc.

People needed

69

Starts

2010-07-01

Expected to finish

2016-09-01

Last updated by the study team

2019-03-13

Who can join

Age: any, up to 5. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients must meet all of the following criteria for enrollment in this study:
• Parent or legal guardian(s) must provide written informed consent prior to any study procedures being performed and must be willing to comply with all study-required procedures. Where appropriate and required by local regulations, patient assent should also be provided prior to any study procedures being performed.
• Documented diagnosis of HPP as indicated by:
• Total serum alkaline phosphatase (ALP) below the lower limit of normal for age NOTE: Historical values for ALP may be used to determine patient eligibility.
• Plasma pyridoxal-5'-phosphate (PLP) above the upper limit of normal (unless patient is receiving pyridoxine for seizures) NOTE: Historical values for PLP may be used to determine patient eligibility.
• Radiographic evidence of HPP at screening, characterized by:
• Flared and frayed metaphyses, and
• Severe, generalized osteopenia, and
• Widened growth plates, and
• Areas of radiolucency or sclerosis
• Two or more of the following HPP-related findings:
• History or presence of: i) Nontraumatic post-natal fracture or ii) Delayed fracture healing
• Nephrocalcinosis or history of elevated serum calcium
• Functional craniosynostosis
• Respiratory compromise or rachitic chest deformity
• Vitamin B6-responsive seizures
• Failure to thrive
• Onset of symptoms prior to 6 months of age
• Chronological age or adjusted age for premature infants born ≤ 37 weeks gestation of ≤ 5 years
• Otherwise medically stable in the opinion of the Investigator and/or Sponsor

You may not qualify if…

• Patients will be excluded from enrollment in this study if they meet any of the following exclusion criteria:
• Clinically significant disease that precludes study participation, in the opinion of the Investigator and/or Sponsor
• Serum calcium or phosphate levels below the normal range
• Current evidence of treatable form of rickets
• Prior treatment with bisphosphonates
• Treatment with an investigational drug within 1 month prior to the start of asfotase alfa treatment
• Current enrollment in any other study involving an investigational new drug, device or treatment for HPP (e.g., bone marrow transplantation)
• Intolerance to the investigational product (IP) or any of its excipients
• Previous participation in the same study
• Family relative of the Investigator

Where it is running

• Children's Hospital & Research Center Oakland — Oakland, California, United States
• Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
• Children's Hospital of Pittsburgh of UPMC — Pittsburgh, Pennsylvania, United States
• Lady Cilento Children's Hospital — South Brisbane, Queensland, Australia
• Royal Children'S Hospital Melbourne — Parkville, Victoria, Australia
• Health Sciences Centre Winnipeg, University of Manitoba — Winnipeg, Manitoba, Canada
• Necker Hospital — Paris, France
• Chu de Toulouse — Toulouse, France
• Universitätskinderklinikum Würzburg — Würzburg, Germany
• Istituto Giannina Gaslini — Genova, Italy
• Ospedale Pediatrico Bambino Gesù — Roma, Italy
• Fukuoka Higashi Medical Hospital — Koga, Fukuoka, Japan
• Ishikawa Prefectural Hospital — Kanazawa, Ishikawa-ken, Japan
• St. Marianna University School of Medicine, Yokohayama City Seibu Hospital — Yokohama, Kanagawa, Japan
• Tokyo Medical University Hospital — Shinjuku, Tokyo, Japan
• Saitama Municipal Hospital — Saitama, Japan
• Federal State Budgetary Institution — Moscow, Russia
• King Faisal Specialist Hospital and Research Center — Riyadh, Saudi Arabia
• Hospital Infantil Universitario Nino Jesus — Madrid, Spain
• Uludag University — Bursa, Turkey (Türkiye)
• Birmingham Children's Hospital — Birmingham, United Kingdom
• Royal Manchester Children'S Hospital — Manchester, United Kingdom
• Sheffield Children'S Hospital — Sheffield, United Kingdom

Full record on ClinicalTrials.gov

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