Dilute Betadine Lavage in the Prevention of Postoperative Infection

Completed · Phase 4

Conditions studied: Prosthesis-Related Infections, Arthroplasty

In brief

The purpose of this study is to examine the efficacy of a dilute betadine solution in reducing infectious complications in revision total knee arthroplasty. The investigators will enroll patients who are scheduled to undergo a revision total knee arthroplasty. Patients will be randomized into two groups. The treatment group will receive a dilute betadine lavage prior to surgical closure for 3 minutes followed by 2000ml of sterile saline irrigation and the control group will receive the 2000ml sterile saline lavage alone.

Key facts

Study ID

NCT01175044

Run by

Rush University Medical Center

People needed

505

Starts

2010-08-01

Expected to finish

2019-07-08

Last updated by the study team

2021-08-17

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Scheduled to undergo revision total knee arthroplasty

You may not qualify if…

• Inability to provide informed consent or to comply with study assessments (e.g. due to cognitive impairment or geographic distance).
• Age ≤ 17.
• Allergy to povidone iodine.
• Any condition requiring antibiotics 14 days prior to arriving for surgery.
• Patients with chronic immunosuppression (such as HIV/AIDS).
• Unable to adhere to follow up schedule and treatment.
• Patients scheduled to undergo revision total knee arthroplasty for infectious reasons.

Where it is running

• Rush University Medical Center — Chicago, Illinois, United States
• Central DuPage Hospital — Winfield, Illinois, United States

Full record on ClinicalTrials.gov

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