Development of a Methamphetamine Early Intervention

Completed · Phase 1/Phase 2

Conditions studied: HIV, Sexual Behavior, Methamphetamine, Behavioral Research

In brief

Methamphetamine abuse has a strong and consistent epidemiologic association with high-risk sexual behavior and both prevalent and incident HIV in men who have sex with men (MSM), and some authorities have advocated methamphetamine treatment as an HIV prevention strategy. However, methamphetamine interventions have not been evaluated in controlled trials, nor have they been implemented and assessed outside of substance abuse treatment programs. This application proposes preliminary investigations to adapt a methamphetamine treatment intervention previously associated with decreased sexual-risk taking among MSM for use as an early intervention among MSM in Seattle, Washington. Sixty methamphetamine-using MSM will be enrolled in a randomized controlled trial of contingency management (CM) versus no intervention. CM participants will have their urine tested for methamphetamine 3 times weekly for 12 weeks, and will receive vouchers of escalating value when their urines test negative; vouchers will be withheld when participants' urines test positive for methamphetamine or participants miss urine testing visits. All participants will undergo urine methamphetamine testing and audio-computer assisted self-interviews on sexual behavior and substance use at baseline and at 6 week intervals for 6 months. Participants will be tested for HIV, syphilis, rectal gonorrhea and chlamydial infection, and pharyngeal gonorrhea at baseline and at 3 and 6 month follow-up. The study will determine how often MSM will initiate and complete the early intervention, and will longitudinally measure unsafe sexual behaviors among intervention and control participants. Study results will determine the feasibility of instituting and studying CM as an early intervention; define whether the intervention is sufficiently promising to justify a larger, definitive randomized controlled trial; and will provide estimates for defining the number of participants such a trial would require.

Key facts

Study ID

NCT01174654

Run by

University of Washington

People needed

127

Starts

2006-12-01

Expected to finish

2009-04-01

Last updated by the study team

2012-12-13

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Anal sex with another man in the month prior to enrollment
• Use of methamphetamine on at least 2 days in the month prior to enrollment

You may not qualify if…

• Plans to move from the study catchment area within 6 months of enrollment
• A mutually monogamous relationships with a man of the same HIV status lasting 2 or more years

Where it is running

• Lifelong AIDS Alliance — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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