Pilot Study: Patients With Chronic Active Graft Versus Host Disease That Have Failed or Not Tolerated Standard Therapy.

Completed

Conditions studied: Blood Stem Cell Transplant Failure, Graft Versus Host Disease

In brief

By doing this study, researchers hope to understand the many changes that occur in the blood of people who have chronic GvHD. This may also help the researcher understand how ECP works and help guide therapy for patients who have chronic GvHD in the future.

Key facts

Study ID

NCT01174277

Run by

University of Kansas Medical Center

People needed

23

Starts

2010-08-01

Expected to finish

2016-02-01

Last updated by the study team

2017-01-10

Who can join

Age: 7 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Allogeneic HSCT recipients who have chronic extensive GvHD and who have failed or have not been able to tolerate conventional therapy
• Platelets ≥ 20,000 without transfusion support
• Weight ≥ 15 kg.
• Stated willingness to use contraception in women of childbearing potential

You may not qualify if…

• Patients who may not be able to tolerate ECP
• Patients who have received Rituximab monoclonal antibody therapy in the past 3 months
• Patients with a known hypersensitivity to psoralens
• Pregnant or breastfeeding
• Patients who are unable to sign informed consent or who do not have a representative to give permission to participate

Where it is running

• University of Kansas Medical Center — Kansas City, Kansas, United States
• Children's Mercy Hospital — Kansas City, Missouri, United States

Full record on ClinicalTrials.gov

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