Effect of Amiodarone on the Procedure Outcome in Long-standing Persistent Atrial Fibrillation Undergoing Pulmonary Vein Antral Isolation

Completed · Phase 3

Conditions studied: Atrial Fibrillation

In brief

This prospective randomized study aims to investigate the effect of continuous versus interrupted use of Amiodarone on the procedure outcome in long-standing persistent (LSP) atrial fibrillation patients undergoing pulmonary vein antral isolation (PVAI).

Key facts

Study ID

NCT01173809

Run by

Texas Cardiac Arrhythmia Research Foundation

People needed

176

Starts

2010-10-01

Expected to finish

2014-07-01

Last updated by the study team

2014-08-21

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• History of LSP AF
• Age > 18 years
• Willing and ability to understand and sign an informed consent
• Patients on chronic Amiodarone therapy (≥ 3 months)

You may not qualify if…

• Unstable angina
• Concomitant treatment with other class I or III antiarrhythmic drugs
• Myocardial infarction within past 3 months)
• Presence of any disease that is likely to shorten life expectancy to < 1 year
• Symptomatic heart failure, NYHA III or IV
• Contraindications for Amiodarone
• Chronic liver diseases
• Pregnant or breast-feeding mothers

Where it is running

• St.David's Medical Center — Austin, Texas, United States

Full record on ClinicalTrials.gov

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