Factors Involved in Obesity-related Inflammation and Insulin Resistance
Stopped early
Conditions studied: Obesity, Insulin Resistance, Inflammation
In brief
In this project, we propose to recruit lean and obese subjects with different ethnic background (African Americans and Caucasians) to study the alterations of lipid and carbohydrate metabolism and determine whether these disturbances are linked to genetic, inflammatory, oxidative stress, and/or nutritional factors. Because systemic inflammation and insulin resistance are frequent features of obesity, we postulate that an unbalanced diet with high saturated- and low omega 3-fatty acids is linked to obesity-related inflammation and insulin resistance. We propose to investigate fatty acid metabolism and determine the links between fatty acid composition and oxidative stress in tissues of lean and obese subjects. We propose the following aims: Specific Aim 1: Evaluate nutrient intake in lean and obese subjects using the standard NHANES Food Questionnaire. Specific Aim 2: Evaluate the fatty acid composition, including omega-3, in adipose tissue depots, blood monocytes and skeletal muscle, and examine the relationship between omega-3 content and inflammatory and oxidative stress markers. Specific Aim 3: Compare the effects of omega-3 and saturated FA supplementation on inflammatory and oxidative stress markers in vitro in adipose tissue explants, preadipocytes and monocyte culture.
Key facts
- Study ID
- NCT01173705
- Run by
- Vanderbilt University
- People needed
- 62
- Starts
- 2011-06-01
- Expected to finish
- 2014-01-01
- Last updated by the study team
- 2017-01-20
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 18-65 years of age
- Undergoing elective abdominal or bariatric surgery
You may not qualify if…
- Intercurrent infections
- Active cancer diagnosis within 5 years
- Use of medications for diabetes or hyperlipidemia
- Use of glucocorticoids or anti-inflammatory drugs
Where it is running
- Vanderbilt University Medical Center — Nashville, Tennessee, United States
Full record on ClinicalTrials.gov
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