Minocycline for Reduction of Radiation Therapy Treatment-Related Symptom Burden in Oropharynx Cancer: A Randomized Study.

Completed · Phase 2 · Has a placebo group

Conditions studied: Oropharynx Cancer

In brief

The goal of this clinical research study is to learn if minocycline can reduce the symptoms reported by patients with oropharynx cancer, nasopharynx cancer, or unknown primary cancer of head and neck, who receive treatment with radiation therapy.

Key facts

Study ID

NCT01173692

Run by

M.D. Anderson Cancer Center

People needed

47

Starts

2010-07-22

Expected to finish

2020-07-07

Last updated by the study team

2021-08-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with a pathologically proven diagnosis of oropharyngeal cancer, nasopharyngeal cancer, or unknown primary cancer of head and neck in MDACC receiving radiation therapy with or without induction chemotherapy.
• Patients > = 18 years old.
• Patients with the above cancers, T0, TX, T1 to T3, N any, M0 receiving IMRT (to unilateral or bilateral neck) at least 64-72 Gy in 6-7 weeks as definitive treatment.
• Patients must have normal renal function test and no prior renal disease: The screening cut off for serum creatinine < upper limit of normal.
• Patients must have normal hepatic function test and no prior liver disease: The screening results for total bilirubin must be < 1.5 times the upper limit of normal. The screening results for the following must be < 2 times the upper limit of normal for patients to be eligible: Alkaline phosphatase (ALP) and Alanine aminotransferase (ALT). The screening results for Aspartate aminotransferase (AST) must be < 2 times the upper limit of normal if available.
• Patients who speak English (due to the novel research and its complexity, we are only accruing English speaking patients to the protocol).
• Patients must be willing to discontinue taking dong quai and/or St John's wort.
• Patients must be willing and able to review, understand, and provide written consent.

You may not qualify if…

• Patients receiving concurrent chemotherapy or concurrent biologic agent.
• Patients who are taking medications or have conditions that potentially preclude use of any study medications or interventions as determined by the treating physician.
• Patients who are enrolled in another symptom management trial or receiving active treatment under another clinical trial.
• Bile duct obstruction or cholelithiasis.
• History of clinically significant cutaneous drug reaction, or a history of clinically significant hypersensitivity reaction, including multiple allergies or drug reaction.
• Pre-existing psychosis or bipolar disorder.
• Hypersensitivity to any tetracyclines.
• Patients on anticoagulants (ie warfarin/heparin).
• Patients with INR > 1.5.
• Patients taking any tetracycline within the last 15 days.
• Patients that are pregnant.
• Patients treated with upfront radical surgery at the primary site (other than diagnostic tonsillectomy or excision).

Where it is running

• University of Texas MD Anderson Cancer Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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