Phamacological Reversal of Airway Instability During Sedation

Completed · Not applicable · Has a placebo group

Conditions studied: Upper Airway Obstruction

In brief

The investigators are attempting to demonstrate a decrease in the frequency and severity of sedation-induced respiratory arrhythmias(central and obstructive apneas) with pharmacological pre-treatment in this pilot project and then eventually to understand the mechanisms behind this decrease. The efficacy and mechanisms of these treatments, while evaluated during sleep in Obstructed Sleep Apnea (OSA) patients, have not been systematically studied during sedation in either normal subjects or OSA patients. The agent to be assessed in this study in physostigmine versus placebo.

Key facts

Study ID

NCT01171118

Run by

University of Rochester

People needed

10

Starts

2009-08-01

Expected to finish

2011-08-01

Last updated by the study team

2015-04-27

Who can join

Age: 18 and older, up to 45. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Ages 18-45
• BMI below 25
• Healthy males

You may not qualify if…

• Psychiatric illness
• Substance abuse
• Airway disorders
• Bleeding abnormatlities
• Claustrophobia
• Sleep apnea.

Where it is running

• University of Rochester Medical Center — Rochester, New York, United States

Full record on ClinicalTrials.gov

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