Enhanced Protein-Energy Provision Via the Enteral Route in Critically Ill Patients

Completed · Not applicable

Conditions studied: Critically Ill

In brief

Critically ill patients are consistently underfed. Feeding protocols are standardized system tools used to guide nutrition practices, but to date have failed to improve delivery of nutrition. The PEP uP Protocol is a new enhanced feeding protocol. Twenty North American Intensive Care Units (ICUs) will assess baseline nutrition practices. Ten ICUs will be randomized to implement the PEP uP Protocol and educational intervention, and ten will be randomized to continue usual care. Nutrition practices will be reevaluated 6 months after baseline. The investigators hypothesize that the PEP uP Protocol will increase delivery of nutrition, and may ultimately lead to improved survival of critical illness.

Key facts

Study ID

NCT01167595

Run by

Clinical Evaluation Research Unit at Kingston General Hospital

People needed

1059

Starts

2010-09-01

Expected to finish

2011-11-01

Last updated by the study team

2021-04-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Critically ill adults (i.e. >18 years of age)
• Mechanically ventilated before or within the first 6 hours of admission to ICU

You may not qualify if…

• Nutrition (either EN or Parenteral Nutrition (PN)) started before admission to ICU
• Not intubated within 6 hours of admission to ICU
• Receiving non-invasive ventilation (i.e. mask ventilation) during the first 6 hours of ICU stay
• Moribund (as evidenced by death within 48 hours of admission to ICU)

Where it is running

• Phoenix Veterans Affairs Health Care System — Phoenix, Arizona, United States
• Medical Center of the Rockies — Loveland, Colorado, United States
• Washington Health Center — Washington D.C., District of Columbia, United States
• Henry Ford Macomb Hospital — Clinton Township, Michigan, United States
• CoxHealth — Springfield, Missouri, United States
• Lakes Region General Hospital — Laconia, New Hampshire, United States
• Nassau University Medical Center — East Meadow, New York, United States
• Vassar Brothers Medical Center — Poughkeepsie, New York, United States
• South Texas Veterans Health Care System Audie L. Murphy Division — San Antonio, Texas, United States
• Foothills Medical Centre — Calgary, Alberta, Canada
• St Paul's Hospital — Vancouver, British Columbia, Canada
• Rouge Valley Health System - Ajax and Pickering Site — Ajax, Ontario, Canada
• William Osler Health Centre - Brampton Civic Campus — Brampton, Ontario, Canada
• William Osler Health Centre - Etobicoke Campus — Etobicoke, Ontario, Canada
• St Joseph's Healthcare — Hamilton, Ontario, Canada
• The Credit Valley Hospital — Mississauga, Ontario, Canada
• Rouge Valley Health System - Centenary Site — Scarborough Village, Ontario, Canada
• Pasqua Hospital — Regina, Saskatchewan, Canada

Full record on ClinicalTrials.gov

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