Short (5 Days) Versus Long (14 Days) Duration of Antimicrobial Therapy for Acute Bacterial Sinusitis in Children
Completed · Not applicable · Has a placebo group
Conditions studied: Sinusitis
In brief
The investigators objective is to compare short course (5 days) to long course (14 days)antibiotics for the treatment of acute bacterial sinusitis in children. The investigators hypothesize that short course therapy will lead to more frequent relapses of sinusitis and will not reduce resistant organisms.
Key facts
- Study ID
- NCT01166945
- Run by
- University of Wisconsin, Madison
- People needed
- 98
- Starts
- 2010-11-01
- Expected to finish
- 2016-02-01
- Last updated by the study team
- 2019-06-10
Who can join
Age: 1 and older, up to 10. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- children with nasal discharge (of any quality) or daytime cough (which may be worse at night) or both persisting for 10 days or more without evidence of improvement.
- families need to be English speaking
You may not qualify if…
- used antibiotics within the last 15 days;
- had symptoms for > 30 days;
- have concurrent streptococcal pharyngitis or acute otitis media (as the standard doses for both of these conditions is 10 days);
- are allergic to penicillin;
- have symptoms that suggest a complication due to acute bacterial sinusitis that necessitates hospitalization, intravenous antibiotics or sub-specialty evaluation
- been diagnosed with either immunodeficiency or anatomic abnormality of the upper respiratory tract
- history of recurrent acute sinusitis (more than 3 episodes in 6 months or 4 episodes in a year)
- history of chronic sinusitis (more than 90 days of respiratory symptoms in this or the previous respiratory season)
- girls who have begun menstruating
Where it is running
- UW Health Pediatrics (Park St) — Madison, Wisconsin, United States
- UW Health Pediatrics (WestTowne) — Madison, Wisconsin, United States
Full record on ClinicalTrials.gov
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