Development of a Bedside Pain Assessment Kit for Postherpetic Neuralgia

Status unconfirmed

Conditions studied: Neuralgia, Herpes Zoster

In brief

Post herpetic neuralgia (PHN) is an undertreated condition. It is a type of neuropathic pain (NP), or pain caused by abnormal activity of sensory nerves. Its mechanisms are not fully understood, and medication trials for PHN pain and other types of NP are frequently unsuccessful. There has been extensive investigation aimed at identifying and understanding the specific mechanisms of NP. While some of these tests are inexpensive and easy to perform at the bedside, many require expensive tools and highly equipped laboratory facilities. Further, there is no standard method for assessment of pain in NP patients. The investigators aim to test a Bedside Sensory Testing Kit (assessment for Neuropathic Pain) on a small number of patients with PHN. The purpose of the Kit is to identify mechanisms of pain. The goal of this research is to design a way to classify patients with PHN based on what mechanisms are causing their pain, since this may help predict the best medications for individual patients.

Key facts

Study ID

NCT01166295

Run by

Analgesic Solutions

People needed

12

Starts

2010-07-01

Expected to finish

2010-11-01

Last updated by the study team

2010-08-05

Who can join

Age: 40 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subject is between 40 and 85 years old.
• Physician documentation of history of postherpetic neuralgia must be provided; pain persisting more than 3 months/90 days after a patient's vesicular rash (shingles) has healed.
• Subject is able to speak, read and write in English and comply with all study procedures;
• Subject is willing to voluntarily sign and date an Informed Consent Form, approved by an IRB, prior to the conduct of any study-specific procedures;
• Subject must be willing to abstain from PRN (as needed) pain medicine for 12 hours prior to the study but may continue their standing doses of pain medicine.

You may not qualify if…

• Subject is pregnant and/or breast-feeding.
• Subjects with additional sources of chronic pain will not be allowed if the severity of pain in additional locations is severe enough to compromise assessment of PHN pain. This will be left to the Investigator's discretion.
• Subject has a medical condition, other than PHN, that is not well-controlled with treatment; or the subject has any clinically significant condition that would, in the opinion of the investigator, preclude study participation, interfere with the assessment of pain, or pose unacceptable risk to the participant.
• Subject has been enrolled in another study within 30 days.
• Subject has a known contact allergy to surgical skin markers.
• In the judgment of the investigator, the subject has a psychiatric or psychological disorder that would interfere with the completion of the study, confound the study results, or pose patient risk.
• Subject has neuropathy or nerve fiber disease other than PHN (e.g., diabetic peripheral neuropathy).

Where it is running

• Analgesic Solutions — Natick, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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