A Comparison of Wear Among Mobile and Fixed Bearing Knee Replacements

Completed

Conditions studied: Osteoarthritis

In brief

The purpose of this study is to determine the amount of polyethylene wear associated with knee replacement designs that incorporate either a fixed or mobile bearing. Tibial polyethylene inserts retrieved from modular total knee replacements during revision operations will be analyzed by obtaining micro-CT images of the retrieved inserts. The components of total volumetric polyethylene loss, including wear associated with the medial articular, lateral articular and backside regions of the insert be quantified by comparing the worn insert with an unworn control. The investigators hypothesize that the fixed bearing inserts where the polyethylene is locked to the metal baseplate will demonstrate more volumetric wear than the mobile bearing inserts that are designed to slide or rotate on the metal baseplate.

Key facts

Study ID

NCT01165957

Run by

Anderson Orthopaedic Research Institute

People needed

24

Starts

2010-06-01

Expected to finish

2012-05-01

Last updated by the study team

2012-08-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• DePuy mobile and fixed bearing polyethylene tibial inserts retrieved after at least 12 months in vivo.
• Inserts terminally sterilized by gas plasma or with gamma radiation in oxygen-free barrier packaging.

You may not qualify if…

• Inserts that were sterilized by gamma radiation and exposed to oxygen in packaging.

Where it is running

• Anderson Orthopaedic Research Institute — Alexandria, Virginia, United States

Full record on ClinicalTrials.gov

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