Detailed Clinical, Biochemical and Genetic Characterization in Gonadotropin-releasing Hormone (GnRH) Deficiency Disorders

Stopped early

Conditions studied: Idiopathic Hypogonadotropic Hypogonadism, Hypothalamic Amenorrhea

In brief

In this study, we will measure levels of reproductive hormones and metabolic markers in subjects with isolated GnRH deficiency disorders and compare them to healthy control populations. Our goals are (1) to chart the range of hormonal and metabolic biomarkers in healthy subjects and those with reproductive disorders and (2) to correlate reproductive and metabolic phenotypes with genetic changes within patients with reproductive disorders and healthy controls.

Key facts

Study ID

NCT01165619

Run by

Massachusetts General Hospital

People needed

50

Starts

2010-06-01

Expected to finish

2010-10-01

Last updated by the study team

2011-05-24

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Over the age of 18 for men
• Between the ages of 18 and 40 for women
• For reproductive disorder population: Current or previous diagnosis of Idiopathic Hypogonadotropic Hypogonadism or Hypothalamic Amenorrhea

You may not qualify if…

• chronic disease (hypertension, high cholesterol, diabetes, asthma, etc)
• polycystic ovarian syndrome for women
• prescription medication use (other than allergy meds) for control populations
• irregular menstrual cycles for healthy female control population (cycle length longer than 35 days or shorter than 25 days. cycle length varies by more than 5 days. less than 9 periods per year)

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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