INCB18424 in Treating Young Patients With Relapsed or Refractory Solid Tumor, Leukemia, or Myeloproliferative Disease

Completed · Phase 1

Conditions studied: Chronic Myeloproliferative Disorders, Leukemia, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms, Unspecified Childhood Solid Tumor, Protocol Specific

In brief

RATIONALE: INCB18424 (Ruxolitinib) may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase 1 clinical trial is studying the side effects and best dose of INCB18424 in treating young patients with relapsed or refractory solid tumor, leukemia, or myeloproliferative disease.

Key facts

Study ID

NCT01164163

Run by

Children's Oncology Group

People needed

49

Starts

2010-09-01

Last updated by the study team

2014-10-23

Who can join

Age: 1 and older, up to 21. Sex: any. Healthy volunteers: not accepted.

Where it is running

• UAB Comprehensive Cancer Center — Birmingham, Alabama, United States
• Children's Hospital of Orange County — Orange, California, United States
• UCSF Helen Diller Family Comprehensive Cancer Center — San Francisco, California, United States
• Children's Hospital Colorado Center for Cancer and Blood Disorders — Aurora, Colorado, United States
• Children's National Medical Center — Washington D.C., District of Columbia, United States
• AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Egleston Campus — Atlanta, Georgia, United States
• Children's Memorial Hospital - Chicago — Chicago, Illinois, United States
• Riley's Children Cancer Center at Riley Hospital for Children — Indianapolis, Indiana, United States
• Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins — Baltimore, Maryland, United States
• Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office — Bethesda, Maryland, United States
• Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute — Boston, Massachusetts, United States
• C.S. Mott Children's Hospital at University of Michigan Medical Center — Ann Arbor, Michigan, United States
• Masonic Cancer Center at University of Minnesota — Minneapolis, Minnesota, United States
• Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis — St Louis, Missouri, United States
• Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center — New York, New York, United States
• Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
• Knight Cancer Institute at Oregon Health and Science University — Portland, Oregon, United States
• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
• Children's Hospital of Pittsburgh of UPMC — Pittsburgh, Pennsylvania, United States
• St. Jude Children's Research Hospital — Memphis, Tennessee, United States
• Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas — Dallas, Texas, United States
• Baylor University Medical Center - Houston — Houston, Texas, United States
• Children's Hospital and Regional Medical Center - Seattle — Seattle, Washington, United States
• Midwest Children's Cancer Center at Children's Hospital of Wisconsin — Milwaukee, Wisconsin, United States

Full record on ClinicalTrials.gov

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