Reduction of Drug Use and HIV Risk Among Out-of-Treatment Methamphetamine Users

Completed · Not applicable

Conditions studied: HIV Infections

In brief

There is a need to identify and test effective strategies to reduce meth use and human immunodeficiency virus (HIV) risk behaviors in heterosexuals. This project will compare the efficacy of a manually-driven HIV testing and counseling (HIV T/C) intervention, with HIV T/C plus a manualized Contingency Management (CM), with HIV T/C plus CM plus a manualized Strengths-Based Case Management (CM/SBCM) model. As HIV T/C is the standard of care, the investigators are testing to determine if the investigators can enhance this standard. The specific aims and hypotheses of this protocol are: 1. To compare the relative efficacy of HIV T/C vs. CM vs. CM/SBCM on reducing drug use, specifically meth use. Hypothesis 1: CM/SBCM will reduce drug use more than those in CM (which will have more reduction than HIV T/C), potentially mediated through increased service utilization. 2. To compare the relative efficacy of HIV T/C vs. CM vs. CM/SBCM on reducing HIV and STI risk behaviors, specifically sex risk behaviors but also needle risk for injection drug users (IDUs). Hypothesis 2: CM/SBCM will have greater decreases in HIV risk behaviors than those in CM (which will have greater decreases than HIV T/C), potentially mediated through reduced drug use. 3. To compare the relative efficacy of HIV T/C vs. CM vs. CM/SBCM on improving mental health status. Hypothesis 3: CM/SBCM will have greater improvements in mental health status than those in CM (which will have greater improvements than HIV T/C), potentially mediated through increased service utilization and reduction of drug use, and potentially moderated by baseline meth use.

Key facts

Study ID: NCT01161485
Run by: University of Colorado, Denver
People needed: 502
Starts: 2010-08-01
Expected to finish: 2016-05-25
Last updated by the study team: 2017-01-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

18 years of age or older
Be competent (not too intoxicated or mentally disabled) to give informed consent at the time of the interview
Meth use (verified through urine drug screening and a self-report of meth use of at least 4 times per month for the last 3 months)
Self-reported sex with someone of the opposite sex in last 30 days
Ability to provide a reliable address and phone number for contact
Not in drug treatment in the past 30 days
Willingness to be tested for HIV at baseline and follow-up
Not transient and no know reason why he/she will not be available for follow-up interviews
Not currently mandated by the criminal justice system to receive treatment based on self-report.

You may not qualify if…

Participation in drug treatment in the past 30 days
Currently participating in another Project Safe study
Pregnant or attempting to become pregnant
Intoxicated or impaired mentally to the point that they cannot voluntarily consent to participate tin the project and/or respond to the interview

Where it is running

Project Safe — Denver, Colorado, United States

Full record on ClinicalTrials.gov

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