Hypnotic Medications and Memory: Effect of Drug Exposure During the Night

Completed · Phase 4 · Has a placebo group

Conditions studied: Sleep, Memory

In brief

The purpose of this study is to determine the effect of two hypnotic medications, zolpidem extended release and zaleplon, on memory. It is expected that a hypnotic with shorter drug duration will allow greater memory consolidation than a hypnotic with longer drug duration.

Key facts

Study ID

NCT01159652

Run by

St. Luke's Hospital, Chesterfield, Missouri

People needed

26

Starts

2010-10-01

Expected to finish

2011-05-01

Last updated by the study team

2014-08-26

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18 to 50 years of age
• no sleep complaints or problems
• good sleep quality per questionnaire
• sufficient time in bed each night

You may not qualify if…

• any clinically significant unstable medical condition
• recent psychiatric disorder
• prior diagnosis or symptoms of a sleep disorder
• recent history of substance abuse
• recent use of prescription hypnotic medication or over-the-counter sleep aid
• recent use of psychotropic medication
• history of adverse reaction to benzodiazepines
• body mass index > 36
• currently pregnant or nursing
• currently working rotating or night shift
• consumption of > 700 mg per day of xanthine-containing food or beverages
• consumption of > 14 units of alcohol per week
• smoke > 1 pack of cigarettes per day, use of chewing tobacco more than 3 times per day, or unable to refrain from smoking or chewing without distress or discomfort while in the sleep laboratory

Where it is running

• St. Luke's Hospital Sleep Medicine and Research Center — Chesterfield, Missouri, United States

Full record on ClinicalTrials.gov

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