Live Kidney Donor Study -Renal Function Study

Completed

Conditions studied: Kidney Donation, Kidney Failure, Kidney Transplantation

In brief

Kidney transplantation from living donors has been shown to carry many benefits over deceased donor transplantation. Because of benefits such as shorter waiting times and improved outcome for transplant recipients, living kidney donation accounts for an increasing number of kidney transplants nationwide. Most published studies about living kidney donation demonstrate that the procedure is safe, but they also emphasize concerns that long-term data on live donor outcomes are insufficient. In particular, data concerning the extent of renal function decline after donation are inadequate. This study will measure glomerular filtration rate (GFR) in previous living donors and aims to more accurately describe renal function after kidney donation.

Key facts

Study ID

NCT01158742

Run by

National Institute of Allergy and Infectious Diseases (NIAID)

People needed

402

Starts

2009-09-01

Expected to finish

2012-06-01

Last updated by the study team

2017-03-27

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Underwent unilateral donor nephrectomy between 5 and 50 years ago; but no later than June 30, 2005 at Mayo Clinic or University of Minnesota
• Alive at the time of study recruitment
• Underwent GFR measurement before and early after donor nephrectomy (Mayo Clinic participants only)
• Underwent GFR measurement late after donor nephrectomy and 3 or more years prior to the invitation to participate in this study (UMN participants only)
• Self reported black race (UAB participants only)
• Negative serum pregnancy test (Total Beta Human Chorionic Gonadotropin (HCG) <5) for women of child-bearing potential

You may not qualify if…

• Less than 5 years out from time of kidney donation
• Inability to contact donor
• Inability or unwillingness to provide informed consent
• Iodine or iodinated contrast allergy.
• Pregnant or breast feeding women

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States
• University of Minnesota — Minneapolis, Minnesota, United States
• Mayo Clinic — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

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