Utility of Vancomycin Loading: A Pharmacokinetic Analysis in Critically Ill Patients

Stopped early · Not applicable

Conditions studied: Infection

In brief

The goal of this clinical research study is to learn if giving a larger than normal "loading dose" of the antibiotic vancomycin before starting standard vancomycin dosing can help patients reach and maintain the needed blood-level of the antibiotic during treatment.

Key facts

Study ID

NCT01157533

Run by

M.D. Anderson Cancer Center

People needed

1

Starts

2010-06-01

Expected to finish

2012-01-01

Last updated by the study team

2013-03-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Admission to MD Anderson Cancer Center Surgical Intensive Care Unit (SICU) under the Thoracic Surgery physician group
• Intravenous vancomycin therapy deemed necessary

You may not qualify if…

• Age less than 18 years
• History of hypersensitivity to vancomycin
• Patient weight greater than 150 kg
• Receival of 1 or more doses of the following agents within 72 hours prior to screening: amphotericin B (lipid, liposomal, or conventional formulation), aminoglycosides, foscarnet and/or intravenous contrast dye.
• Prior exposure (within 7 days) to intravenous vancomycin
• Current renal insufficiency defined as baseline Scr >/= 1.5 mg/dL, or increase in baseline serum creatinine (SCr) by >/= 0.5 mg/dL within the last 2 days, or estimated creatinine clearance (CrCl) </= 30 mL/min by Cockcroft-Gault equation.
• Current need for hemodialysis or continuous renal replacement therapy

Where it is running

• UT MD Anderson Cancer Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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