Effective Treatment of Sleep Apnea in Prediabetes to Reduce Cardiometabolic Risk
Completed · Not applicable · Has a placebo group
Conditions studied: Diabetes, Sleep Apnea
In brief
Although obstructive sleep apnea (OSA) is associated with impaired glucose tolerance and diabetes, it remains unclear whether OSA treatment with continuous positive airway pressure (CPAP) has metabolic benefits. The objective of this study is to determine the effect of 8-hour nightly CPAP treatment on glucose metabolism in individuals with prediabetes and OSA.
Key facts
- Study ID
- NCT01156116
- Run by
- University of Chicago
- People needed
- 39
- Starts
- 2009-10-01
- Expected to finish
- 2012-10-01
- Last updated by the study team
- 2015-05-27
Who can join
Age: 45 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Overweight or obese adults (age ≥45 yrs and BMI ≥25 kg/m2)
- prediabetes and OSA (AHI ≥ 5)
- regular life styles and schedules (no shift work in the past 6 months, no travel across time zones during the past 4 weeks)
- habitual bedtimes of at least 6 hours but not exceeding 9 hours will be eligible.
- not to take any medications during the study period with the exception of antihypertensives and lipid lowering agents
- not on hormone replacement therapy.
- have sedentary activities and no competitive athletes or subjects with high exercise levels.
You may not qualify if…
- previous or current treatment with supplemental oxygen
- requirement of supplemental oxygen or bi-level positive airway pressure for OSA treatment during titration
- presence of active infection, psychiatric disease or history of other significant illness (e.g., myocardial infarction, congestive heart failure, stroke, arrhythmia, chronic kidney or liver disease0
- clinical depression as evidenced by a score >16 in CES-D scale
- smoking, or routine alcohol use (more than 2 drinks per day), or excessive caffeine intake (>300mg per day)
Where it is running
- The University of Chicago — Chicago, Illinois, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.