Increased Gut Permeability to Lipopolysaccharides (LPS) in Parkinson's Disease

Completed

Conditions studied: Parkinson's Disease, Multiple System Atrophy

In brief

The gut may be a portal of entry for agents that cause or contribute to the causes of Parkinson's disease (PD). The investigators are studying changes in the normal population of gut flora and in intestinal permeability and their associations with early PD.

Key facts

Study ID

NCT01155492

Run by

Rush University Medical Center

People needed

43

Starts

2007-09-01

Expected to finish

2013-02-01

Last updated by the study team

2013-05-30

Who can join

Age: 25 and older. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• Secondary or atypical parkinsonism other than Multiple System Atrophy
• Occupation or medical treatment known to influence intestinal flora
• Organic gastrointestinal disease other than hiatal hernia or hemorrhoids; history of gastrointestinal surgery other than remote appendectomy or cholecystectomy.
• Acute or chronic medical illness that would confound study results.
• Coagulopathy or use of anticoagulant medications (including aspirin).
• Chronic use of diuretics

Where it is running

• Rush University Medical Center — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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