Sex Hormones and Orthostatic Tolerance

Completed · Phase 2

Conditions studied: Orthostatic Intolerance

In brief

This study is designed to determine the causes of "orthostatic intolerance" which occurs more commonly in women than in men. Orthostatic tolerance is the ability to remain standing up right for long periods of time, or to avoid dizziness when moving to standing from a seated or lying position.

Key facts

Study ID

NCT01153581

Run by

Yale University

People needed

109

Starts

2006-02-01

Expected to finish

2013-05-01

Last updated by the study team

2018-12-13

Who can join

Age: 18 and older, up to 34. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Healthy, English-speaking non-smoking women age 18- 34 with regular menses

You may not qualify if…

• Gynecologic:
• current or past estrogen-dependent neoplasia,
• unexplained vaginal bleeding,
• history of uterine fibroids,
• current pregnancy,
• known or suspected breast or uterine cancer,
• partial or complete hysterectomy
• Cardiac:
• myocardial infarction, ventricle tachycardia or fibrillation,
• angina,
• valvular disease,
• congestive heart failure, orthopnea, paroxysmal nocturnal dyspnea,
• current arrhythmias,
• prosthetic valves
• Pulmonary:
• current cigarette smokers, or pipe or cigar smokers,
• chronic obstructive pulmonary disease,
• adult asthma,
• dyspnea on exertion,
• current bronchitis, pneumonia, or tuberculosis,
• lung carcinoma,
• pulmonary embolus, recent
• Vascular:
• claudication or history of peripheral vascular disease,
• abdominal or thoracic aortic aneurysm, or repair of same,

Where it is running

• John B. Pierce Laboratory — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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